Research
We have compiled a comprehensive library of the vast body of available research on chlorella. The list below provides examples of the extensive research that has been conducted into the health benefits of chlorella.
- Rodriguez-Garcia, Ignacio and Jose L. Guil-Guerrero. "Evaluation of the antioxidant activity of three microalgal species for use as dietary supplements and in the preservation of foods." Food Chemistry 108.3 (2008): 1023-26.
- Ugwu, C. U., H. Aoyagi, and H. Uchiyama. "Photobioreactors for mass cultivation of algae." Bioresource Technology 99.10 (2008): 4021-28.
- Chu, Wan-Loy, Yike-Chu See, and Siew-Moi Phang. "Use of immobilised Chlorella vulgaris for the removal of colour from textile dyes." Journal of Applied Phycology.
- Ellen and Olivier De Clerck. "Gain and loss of elongation factor genes in green algae." BMC Evolutionary Biology 9 (2009): 39+.
- Van Etten, J. L., D. E. Burbank, Y. Xia, and R. H. Meints. "Growth cycle of a virus, PBCV-1, that infects Chlorella-like algae." Virology 126.1 (1983): 117-25.
- Mason, Russ. "Chlorella and Spirulina: Green Supplements for Balancing the Body." Alternative and Complementary Therapies 7.3 (2001): 161-65.
- Horikoshi, T., A. Nakajima, and T. Sakaguchi. "Uptake of uranium by various cell fractions of Chlorella regularis." Radioisotopes 28.8 (1979): 485-88.
- Ben-Bassat, D. and A. M. Mayer. "Reduction of Mercury Chloride by Chlorella: Evidence for a Reducing Factor." Physiologia Plantarum 40.3 (1977): 157-62.
- Chong, A. "Performance of different microalgal species in removing nickel and zinc from industrial wastewater." Chemosphere 41.1-2 (2000): 251-57.
- Merchant, Randall E., Cynthia A. Carmack, and Christopher M. Wise. "Nutritional Supplementation withChlorella pyrenoidosa for patients with fibromyalgia syndrome: a pilot study." Phytotherapy Research 14.3 (2000): 167-73.
- Singh, A., S. P. Singh, and R. Bamezai. "Inhibitory potential of Chlorella vulgaris (E-25) on mouse skin papillomagenesis and xenobiotic detoxication system." Anticancer research 19.3A (1999): 1887-91.
- Tanaka, K., et al. "Oral administration of a unicellular green algae, Chlorella vulgaris, prevents stress-induced ulcer." Planta medica 63.5 (1997): 465-66.
- Wolf, L. "Bioregeneration with maltose excreting Chlorella: system concept, technological development, and experiments." Advances in space biology and medicine 6 (1997): 255-74.
- Singh, S. P., A. B. Tiku, and P. C. Kesavan. "Post-exposure radioprotection by Chlorella vulgaris (E-25) in mice." Indian journal of experimental biology 33.8 (1995): 612-15.
- Sarma, L., A. B. Tiku, P. C. Kesavan, and M. Ogaki. "Evaluation of radioprotective action of a mutant (E-25) form of Chlorella vulgaris in mice." Journal of radiation research 34.4 (1993): 277-84.
- Kay, R. A. "Microalgae as food and supplement." Critical reviews in food science and nutrition 30.6 (1991): 555-73.
- Matsuura, E., et al. "Effect of chlorella on rats with iron deficient anemia." The Kitasato archives of experimental medicine 64.4 (1991): 193-204.
- Konishi, F., et al. "Enhanced resistance against Escherichia coli infection by subcutaneous administration of the hot-water extract of Chlorella vulgaris in cyclophosphamide-treated mice." Cancer immunology, immunotherapy : CII 32.1 (1990): 1-7.
- Ibusuki, K. and Y. Minamishima. "Effect of Chlorella vulgaris extracts on murine cytomegalovirus infections." Natural immunity and cell growth regulation 9.2 (1990): 121-28.
- Rotkovska, D., A. Vacek, and A. Bartonickova. "The radioprotective effects of aqueous extract from chlorococcal freshwater algae (Chlorella kessleri) in mice and rats." Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 165.11 (1989): 813-16.
- Sano, T. and Y. Tanaka. "Effect of dried, powdered Chlorella vulgaris on experimental atherosclerosis and alimentary hypercholesterolemia in cholesterol-fed rabbits." Artery 14.2 (1987): 76-84.
- Wang, L. F., J. K. Lin, and Y. C. Tung. "Protective effect of Chlorella on the hepatic damage induced by ethionine in rats." Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association 78.12 (1979): 1010-19.
- Hasegawa, T., et al. "Effect of hot water extract of Chlorella vulgaris on cytokine expression patterns in mice with murine acquired immunodeficiency syndrome after infection with Listeria monocytogenes." Immunopharmacology 35.3 (1997): 273-82.
- Janczyk, P., H. Franke, and W. Souffrant. "Nutritional value of Chlorella vulgaris: Effects of ultrasonication and electroporation on digestibility in rats." Animal Feed Science and Technology 132.1-2 (2007): 163-69.
- Travieso, L., et al. "Heavy Metal Removal by Microalgae." Bulletin of Environmental Contamination and Toxicology 62.2 (1999): 144-51.
- Hagino, N. and S. Ichimura. "[Effect of chlorella on fecal and urinary cadmium excretion in "Itai-itai" disease]." Nippon eiseigaku zasshi. Japanese journal of hygiene 30.1 (1975).
- Morita, Kunimasa, Takahiko Matsueda, Takao Iida, and Takashi Hasegawa. "Chlorella Accelerates Dioxin Excretion in Rats." J. Nutr. 129.9 (1999): 1731-36.
- Marktl, W. "[Micronutrients in cancer prevention]." Forschende Komplementarmedizin 6.5 (1999): 248-55.
- Okamoto, K., et al. "Effects of chlorella alkali extract on blood pressure in SHR." Japanese heart journal 19.4 (1978): 622-23.
- Negishi, T., H. Rai, and H. Hayatsu. "Antigenotoxic activity of natural chlorophylls." Mutation research 376.1-2 (1997): 97?100.
- Singh, A., S. P. Singh, and R. Bamezai. "Modulatory influence of chlorophyllin on the mouse skin papillomagenesis and xenobiotic detoxication system." Carcinogenesis 17.7 (1996): 1459-63.
- Negishi, Tomoe, Sakae Arimoto, Chiharu Nishizaki, and Hikoya Hayatsu. "Inhibitory effect of chlorophyll on the genotoxicity of 3-amino-1-methyl-5H-pyrido[4,3-b indole (Trp-P-2)." Carcinogenesis 10.1 (1989): 145-49.
- Singh, A., S. P. Singh, and R. Bamezai. "Perinatal influence of Chlorella vulgaris (E-25) on hepatic drug metabolizing enzymes and lipid peroxidation." Anticancer research 18.3A (1998): 1509-14.
- Merchant, Randall E., Charles D. Rice, and Harold F. Young. "Dietary Chlorella pyrenoidosa for patients with malignant glioma: Effects on immunocompetence, quality of life, and survival." Phytotherapy Research 4.6 (1990): 220-31.
- Hasegawa, T. "Hot water extracts of Chlorella vulgaris reduce opportunistic infection with Listeria monocytogenes in C57BL/6 mice infected with LP-BM5 murine leukemia viruses." International Journal of Immunopharmacology 17.6 (1995): 505-12.
- Tanaka, K., et al. "Augmentation of host defense by a unicellular green alga, Chlorella vulgaris, to Escherichia coli infection." Infection and immunity 53.2 (1986): 267-71.
- Son, Young Ae A., Jee Ae A. Shim, Soyoung Hong, and Mi Kyung K. Kim. "Intake of Chlorella vulgaris Improves Antioxidative Capacity in Rats Oxidatively Stressed with Dietary Cadmium." Annals of nutrition & metabolism 54.1 (2009): 7-14.
- Konishi, Fumiko, et al. "Antitumor effect induced by a hot water extract of Chlorella vulgaris (CE): Resistance to meth-A tumor growth mediated by CE-induced polymorphonuclear leukocytes." Cancer Immunology, Immunotherapy 19.2 (1985): 73?78.
- Tanaka, Kuniaki, et al. "Augmentation of antitumor resistance by a strain of unicellular green algae, Chlorella vulgaris." Cancer Immunology, Immunotherapy 17.2 (1984): 90-94.
- Noda, K., et al. "A water-soluble antitumor glycoprotein from Chlorella vulgaris." Planta medica 62.5 (1996): 423-26.
- Tanaka, K., et al. "A novel glycoprotein obtained from Chlorella vulgaris strain CK22 shows antimetastatic immunopotentiation." Cancer Immunology, Immunotherapy 45.6 (1998): 313-20.
- Konishi, F., et al. "Protective effect of an acidic glycoprotein obtained from culture of Chlorella vulgaris against myelosuppression by 5-fluorouracil." Cancer immunology, immunotherapy : CII 42.5 (1996): 268-74.
- Tanaka, K., et al. "Oral administration of Chlorella vulgaris augments concomitant antitumor immunity." Immunopharmacology and immunotoxicology 12.2 (1990): 277-91.
- Suarez, E. R., et al. "Isolation, characterization and structural determination of a unique type of arabinogalactan from an immunostimulatory extract of Chlorella pyrenoidosa." Carbohydrate research 340.8 (2005): 1489-98.
- Pugh, N., et al. "Isolation of three high molecular weight polysaccharide preparations with potent immunostimulatory activity from Spirulina platensis, aphanizomenon flos-aquae and Chlorella pyrenoidosa." Planta medica 67.8 (2001): 737-42.
- Kralovec, J., et al. "An aqueous extract inhibits IL-5 production by mast cells in vitro and reduces ovalbumin-induced eosinophil infiltration in the airway in mice in vivo." International Immunopharmacology 5.4 (2005): 689-98.
- Hidaka, S., Y. Okamoto, and M. Arita. "A hot water extract of Chlorella pyrenoidosa reduces body weight and serum lipids in ovariectomized rats." Phytotherapy research : PTR 18.2 (2004): 164-68.
- Hsu, T., et al. "DNA mismatch binding activities in extracts and affinity isolation of G-T mismatch binding proteins." Plant Physiology and Biochemistry (2005).
- Halperin, Scott A., et al. "Safety and immunoenhancing effect of a Chlorella-derived dietary supplement in healthy adults undergoing influenza vaccination: randomized, double-blind, placebo-controlled trial." CMAJ 169.2 (2003): 111-17.
- Kim, Kang-Woong, et al. "Effects of Dietary Chlorella ellipsoidea Supplementation on Growth, Blood Characteristics, and Whole-Body Composition in Juvenile Japanese Flounder Paralichthys olivaceus." Journal of the World Aquaculture Society 33.4 (2002): 425-31.
- Dantas, D. "Effects of Chlorella vulgaris on bone marrow progenitor cells of mice infected with Listeria monocytogenes." International Journal of Immunopharmacology 21.8 (1999): 499-508.
- Vijayavel, K., C. Anbuselvam, and M. Balasubramanian. "Antioxidant effect of the marine algae Chlorella vulgaris against naphthalene-induced oxidative stress in the albino rats." Molecular and Cellular Biochemistry 303.1 (2007): 39-44.
- Hasegawa, T., et al. "Oral administration of hot water extracts of Chlorella vulgaris reduces IgE production against milk casein in mice." International journal of immunopharmacology 21.5 (1999): 311-23.
- Morimoto, T., et al. "Anti-tumour-promoting glyceroglycolipids from the green alga, Chlorella vulgaris." Phytochemistry 40.5 (1995): 1433-37.
- Krishnamurthy, S. and Raymond M. Frederick. "Using biopolymers to remove heavy metals from soil and water." Remediation Journal 4.2 (1994): 235-44.
- Pore, R. S. "Detoxification of chlordecone poisoned rats with chlorella and chlorella derived sporopollenin." Drug and chemical toxicology 7.1 (1984): 57-71.
- Rauma, Anna-Liisa, Riitta Torronen, Osmo Hanninen, and Hannu Mykkanen. "Vitamin B-12 Status of Long-Term Adherents of a Strict Uncooked Vegan Diet ("Living Food Diet") Is Compromised." J. Nutr. 125.10 (1995): 2511-15.
- Huang, Chieh-Chen, et al. "Expression of mercuric reductase from Bacillus megaterium MB1 in eukaryotic microalga Chlorella sp. DT: an approach for mercury phytoremediation." Applied Microbiology and Biotechnology (2006): 197-205.
- Reyessuarez, E., et al. "First isolation and structural determination of cyclic ??-(1?Ui2)-glucans from an alga, Chlorella pyrenoidosa." Carbohydrate Research 343.15 (2008): 262-333.
- Ben-Bassat, D. and A. M. Mayer. "Volatilization of Mercury by Algae." Physiologia Plantarum 33.2 (1975): 128-32.
- Kungolos, Athanassios and Isao Aoyama. "Interaction effect, food effect, and bioaccumulation of cadmium and chromium for the system daphnia magna-chlorella ellipsoidea." Environmental Toxicology & Water Quality 8.4 (1993): 351-69.
- Kaplan, Drora, Daniel Christiaen, and Shoshana M. Arad. "Chelating Properties of Extracellular Polysaccharides from Chlorella spp." Appl. Environ. Microbiol. 53.12 (1987): 2953-56.
- Allnutt, Thomas F. C. and Walter D. Bonner. "Characterization of Iron Uptake from Ferrioxamine B by Chlorella vulgaris." Plant Physiol. 85.3 (1987): 746-50.
- Queiroz, M. "Protective effects of Chlorella vulgaris in lead-exposed mice infected with Listeria monocytogenes." International Immunopharmacology 3.6 (2003): 889?900.
- Mercola, Joseph and Dietrich Klinghardt. "Mercury Toxicity and Systemic Elimination Agents." Journal of Nutritional & Environmental Medicine (2001): 53?62.
- Wilkinson, S., K. Goulding, and P. Robinson. "Mercury removal by immobilized algae in batch culture systems." Journal of Applied Phycology 2.3 (1990): 223-30.
- Ballatori, N. and T. W. Clarkson. "Developmental changes in the biliary excretion of methylmercury and glutathione." Science 216.4541 (1982): 61-63.
- Siripornadulsil, S., S. Traina, D. P. Verma, and R. T. Sayre. "Molecular mechanisms of proline-mediated tolerance to toxic heavy metals in transgenic microalgae." The Plant cell 14.11 (2002): 2837-47.
- Shim, Jae-Young, et al. "Protective Effects of Chlorella vulgaris on Liver Toxicity in Cadmium-Administered Rats." Journal of Medicinal Food 11.3 (2008): 479-85.
- Queiroz, M., et al. "Chlorella vulgaris up-modulation of myelossupression induced by lead: The role of stromal cells." Food and Chemical Toxicology 46.9 (2008): 3147-54.
- Andrade, A. "Proton and metal binding capacity of the green freshwater alga." Process Biochemistry (2004).
- Huang, Z., et al. "Growth-inhibitory and metal-binding proteins in Chlorella vulgaris exposed to cadmium or zinc." Aquatic Toxicology 91.1 (2009): 54-61.
- Carr, H. P., F. A. Carino, M. S. Yang, and M. H. Wong. "Characterization of the cadmium-binding capacity of Chlorella vulgaris." Bulletin of environmental contamination and toxicology 60.3 (1998): 433-40.
- Nagano, T., Y. Suketa, and S. Okada. "[Absorption and excretion of Chlorella ellipsoidea cadmium binding protein in rats]." Nippon eiseigaku zasshi. Japanese journal of hygiene 38.4 (1983): 741-47.
- Morelli, E. and E. Pratesi. "Production of Phytochelatins in the Marine Diatom Phaeodactylum tricornutum in Response to Copper and Cadmium Exposure." Bulletin of Environmental Contamination and Toxicology 59.4 (1997): 657-64.
- NORTHCOTE, D. H., K. J. GOULDING, and R. W. HORNE. "The chemical composition and structure of the cell wall of Chlorella pyrenoidosa." The Biochemical journal 70.3 (1958): 391-97.
- Peralesvela, H., J. Penacastro, and R. Canizaresvillanueva. "Heavy metal detoxification in eukaryotic microalgae." Chemosphere 64.1 (2006): 1?10.
- Merchant, R. E. and C. A. Andre. "A review of recent clinical trials of the nutritional supplement Chlorella pyrenoidosa in the treatment of fibromyalgia, hypertension, and ulcerative colitis." Alternative therapies in health and medicine 7.3 (2001): 79-91.
- Mizoguchi, Toru, et al. "Nutrigenomic Studies of Effects of Chlorella on Subjects with High-Risk Factors for Lifestyle-Related Disease." Journal of Medicinal Food 11.3 (2008): 395-404.
- Nakano, S., H. Takekoshi, and M. Nakano. "Chlorella (Chlorella pyrenoidosa) supplementation decreases dioxin and increases immunoglobulin a concentrations in breast milk." Journal of medicinal food 10.1 (2007): 134-42.
- Cicero, Arrigo F., Antonio V. Gaddi, and Claudio Borghi. "Complementary and Alternative Medicine for Hypertension: What Evidence is There for Herbalist Suggestions?" Evidence-Based Integrative Medicine 2.1 (2005): 47-55.
- Pore, Scott R. "Detoxification of Chlordecone Poisoned Rats with Chlorella and Chlorella Derived Sporopollenin." Drug and Chemical Toxicology 7.1 (1984): 57-71.
- Leong, C. C., N. I. Syed, and F. L. Lorscheider. "Retrograde degeneration of neurite membrane structural integrity of nerve growth cones following in vitro exposure to mercury." Neuroreport 12.4 (2001): 733-37.
- Bjorkman, Lars, et al. "Mercury in human brain, blood, muscle and toenails in relation to exposure: an autopsy study." Environmental Health 6.1 (2007): 30+.
- Nylander, M., L. Friberg, and B. Lind. "Mercury concentrations in the human brain and kidneys in relation to exposure from dental amalgam fillings." Swedish dental journal 11.5 (1987): 179-87.
- Friberg, L. and N. K. Mottet. "Accumulation of methylmercury and inorganic mercury in the brain." Biological trace element research 21 (1989): 201-06.
- Langworth, S., C. G. Elinder, and A. Akesson. "Mercury exposure from dental fillings. I. Mercury concentrations in blood and urine." Swedish dental journal 12.1-2 (1988): 69-70.
- Nylander, M., L. Friberg, and J. Weiner. "Muscle biopsy as an indicator for predicting mercury concentrations in the brain." British journal of industrial medicine 47.8 (1990): 575-76.
- Dalen, K. "Memory functions in persons with dental amalgam." Journal of Dentistry 31.7 (2003): 487-92.
- Pandit, G., S. Jha, R. Tripathi, and T. Krishnamoorthy. "Intake of methyl mercury by the population of Mumbai, India." Science of The Total Environment 205.2-3 (1997): 267-70.
- Nylander, M. and J. Weiner. "Mercury and selenium concentrations and their interrelations in organs from dental staff and the general population." British journal of industrial medicine 48.11 (1991): 729-34.
- Summers, A. O., et al. "Mercury released from dental "silver" fillings provokes an increase in mercury- and antibiotic-resistant bacteria in oral and intestinal floras of primates." Antimicrobial agents and chemotherapy 37.4 (1993): 825-34.
- Hahn, L. J., et al. "Dental "silver" tooth fillings: a source of mercury exposure revealed by whole-body image scan and tissue analysis." FASEB J. 3.14 (1989): 2641-46.
- Peraza, M. A., et al. "Effects of micronutrients on metal toxicity." Environmental health perspectives 106 Suppl 1 (1998): 203-16.
- Gebel, T. and H. Dunkelberg. "[Influence of chewing gum consumption and dental contact of amalgam fillings to different metal restorations on urine mercury content]." Zentralblatt fur Hygiene und Umweltmedizin = International journal of hygiene and environmental medicine 199.1 (1996): 69-75.
- Tsuji, J. S., et al. "Evaluation of mercury in urine as an indicator of exposure to low levels of mercury vapor." Environmental health perspectives 111.4 (2003): 623-30.
- Gali, N., et al. "Dental amalgam mercury exposure in rats." Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 12.3 (1999): 227-31.






